One man aged in his 50s sustained serious injuries though his exact condition is unknown.
The second male is reported to be in a non-life threatening condition.
Both victims have been rushed to hospital by emergency services.
The incident took place along Winchelsea Road near the centre of Tottenham.
Thus far no arrests have been reported.
Police remain on the ground and a crime scene is in place.
Separately on Wednesday a man was charged following a shooting which took place on Middleton Road, in Hackney, on Monday.
According to the Metropolitan Police website the 28-year-old suspect has been charged with “five counts of attempted murder and one count of possession of a firearm with intent to endanger life”.
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A 25-year-old man who received injuries during the incident remains in a critical, but stable, condition in hospital.
The suspect will appear at Thames Magistrates’ Court on Thursday.
Anyone with information about the attack is urged to contact police by calling 101 and quoting Cad 7439/14Dec.
They also have the option of calling Crimestoppers anonymously via 0800 555 111.
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On Sunday evening a 23-year-old man was stabbed dead in Harrow.
Two teenagers were injured in the same incident and received hospital treatment.
Dr Claire Hind, from the Specialist Crime Command, commented: “This is another tragic incident in which a young man has lost his life.
“We are working tirelessly to establish the circumstances of what happened and find those responsible; and I would appeal for any witnesses to come forward with information they believe may assist the investigation.”